Genomics - Funding

Oregon State University Genome Research and Biocomputing 2010 ...

by Conor O'Brien

This includes chromatin immunoprecipitation assays to demonstrate that methylation at the locus of a key circadian clock regulator is necessary to its proper function, a mutant screen that eventually demonstrated phosphorylation of a protein... My take on his talk: We’re all aware of the need to communicate our work more broadly and the likelihood of shrinking federal research budgets, but Spinrad didn’t have suggestions for how to address these problems besides attempting to give talks... Like the circadian clock in mammals and insects, the basis of the Neurospora clock is a heterodimer that autoregulates the transcription of its own genes. Natural variation, in a genetically tractable context, can thus be used to understand the molecular genetic basis of a phenotype and the environmental context which maintains it. Richard Spinrad, “OSU Research Now, Next, and After Next. Spinrad discussed the present and future of academic research, with a focus on the need to better communicate science to the general public and to secure future sources of funding. basic research will need to find other sources of support and corporations will be one of those sources. such genetic variation has an advantage over lab-induced mutations in that it is maintained by natural selection, whereas mutagenesis studies mostly produce phenotypes of large effect that would never survive in nature. Most funding (about two thirds of OSU’s research budget by the look of his pie chart) comes from the federal government, while industry and non-profits made up another two percent each. Dunlap works on the circadian clock in Neurospora, a filamentous fungi. Dunlap’s lab has done some hard-core molecular work to dissect the basis of this autoregulation. This is one of the better understood molecular genetic pathways, but Dunlap reminded us how much work remains. There is natural variation in at least one Neurospora circadian phenotype. Jay Dunlap, “Genetic and Molecular Dissection of a Simple Circadian System”. This will be a quick post of some impressions from yesterday and today’s Center for Genome Research and Biocomputing (CGRB) Fall Conference at Oregon State University. This autoregulation gives rise to the daily rhythmic expression characteristic of a circadian clock. He discussed the need to make up for the expected federal research budget reductions. I’m sure he’s been working on such ideas, I would like to have seen his talk include some. One opportunity Spinrad mentioned is better partnerships with industry....

What is Genomics - Full Length

Were pleased to present our latest video, What is Genomics? developed in collaboration with Ontario Genomics Institute and Genome British Columbia ...

Rosetta Genomics Achieves Major Commercial Milestone by Obtaining Medicare ...

21.05.12

, A leading developer and provider of microRNA-based molecular diagnostic tests, today announced that Novitas, the designated Medicare Administrative Contractor for the Company's miRview(R) mets^2 assay, has informed Rosetta that it plans to cover this assay for all Medicare beneficiaries. MiRview(R) mets^2 accurately identifies the primary tumor of origin in primary and metastatic cancer including Cancer of Unknown or Uncertain Primary ("CUP").

"This is a major commercial achievement for Rosetta Genomics as Medicare coverage is a critical step toward widespread commercial adoption and payment for our lead diagnostic assay, miRview(R) mets^2, and enables access to this clinically valuable test to Medicare patients. This decision is important not only because Medicare is the largest U.S. payor, covering a large percentage of the patients for whom miRview(R) mets^2 has been ordered historically and would be expected to be ordered in the future, but also because private payors often look to Medicare's decisions when setting their own reimbursement policies," noted Kenneth A. Berlin, President and Chief Executive Officer of Rosetta Genomics. "We are particularly pleased with how rapidly we obtained Medicare coverage, as we launched our direct selling effort in the U.S. just one year ago.

Source: MarketWatch (press release)

How does a person with a programming background break into the genomics or biotechnology field?

Jan 08, 2008 by superSymmetric | Posted in Technology

I am an application developer with a strong interest in biotechnology, genomics to be more specific. It seems like I never seen any jobs advertised for IT positions in these fields. It is hard, or basically impossible, for someone with a degree in programming

If you are looking to do join a pure research company (I would put pharamceuticals in that category), then you will have a tough time.

What you might want to try is to get into one of the many instrumentation companies that feed the research

Have a scientastic day! | Jan 08, 2008

If you are looking to do join a pure research company (I would put pharamceuticals in that category), then you will have a tough time.

What you might want to try is to get into one of the many instrumentation companies that feed the research

Raymond W | Jan 08, 2008

How does Genomics, Proteomics and Bioinformatics help in Target Discovery?

Oct 11, 2007 by PIPI B | Posted in Medicine

Like the title say, I would like to know how these helps in Target Discovery. Please be as clear as possible. I feel that the target is discovered based on "theory". For example if you have a heartbeat disorder, you probably want to target the

From a simple point of view, both of the "omics" make use of bioinformatics to look at huge amounts of data; genomics for genes and proteomics for proteins.

They can be used for Target Discovery in a variety of ways. One example

Prof Kevin | Oct 11, 2007