ReportsandReports – Animal Models for Therapeutic Strategies
Although pharmaceutical companies have long employed animal models based on such mammalian species as mice and rats, dogs, cats, pigs, and primates, more recently the pharmaceutical/biotechnology industry has also adopted several invertebrate and... A major reason why the pharmaceutical/biotechnology industry needs new animal models is because poorly predictive animal models are a major cause of drug attrition during development. Among model organisms, it is model animals that have had a central place in medical research and in pharmaceutical and biotechnology company research, including drug discovery, preclinical studies, and toxicology. The use of animal models in developing novel therapeutic strategies for human diseases overlaps with basic research that uses animal models to understand physiological and disease pathways. Cellular models based on iPS will be used in screening (which may in some cases reduce the numbers of animals needed in a drug discovery program) and to provide information on human disease pathways to supplement information derived from studies... Researchers use animal models in basic research, in developing new therapeutic strategies for treating human diseases, and in drug discovery research (including target identification and validation, drug screening and lead optimization, and... Information derived from cellular models, and in some cases the cells themselves, may also be used to design new animal models to more faithfully model human diseases. This early stage technology may allow researchers to develop disease models based on cells from people with such genetically determined diseases as spinal muscular atrophy (SMA), Parkinson’s disease, Huntington’s disease, Duchenne and Becker... Researchers therefore need to continue to use animal models, which are whole, living systems that model physiology—not just cell and molecular biology. Due to the poor predictivity of many animal models, some researchers would like to work with “human models” based on induced pluripotent stem (iPS) cells. , which more faithfully model the cellular basis of these diseases than animal models. The creation of new animal models is an important part of animal-based therapeutic strategy research. The use of animal models in development of novel therapeutic strategies is the main emphasis of this report. This is especially true in therapeutic areas (e. g. , oncology and central nervous system [CNS] disease) in which animal models are the most unpredictive. But its aim is to achieve knowledge of pathways and targets in a disease that leads to the development of new paradigms for discovery and development of drugs or other therapeutics. It thus also overlaps with use of animal models in drug discovery. Browse complete Animal Models for Therapeutic Strategies Report. The adoption of invertebrate and zebrafish animal models by industry has been driven by the advent of genomics, especially the finding that not only genes, but also pathways, tend to be conserved during evolution....
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